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Synthesis and investigation of the chemical and physicochemical properties of 6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2,3-dihydro-2-indolinones

✍ Scribed by T. V. Golovko; N. P. Solov'eva; O. S. Anisimova; V. G. Granik


Book ID
105535139
Publisher
Springer US
Year
1999
Tongue
English
Weight
425 KB
Volume
35
Category
Article
ISSN
0009-3122

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We have synthesized 14C-and 2H-labeled 1,3-dihydro-3,3dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H\_-indol-2one (LY195115), an extremely potent, orally-effective cardiotonic with inotropic and vasodilator activities. '\*C-label was introduced in the antepenultimate step by reaction of a B-