Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-spiro[cycloalkane-1,3'-[3H]indol]-2'(1'H)-ones
β Scribed by Robertson, David W.; Krushinski, Joseph H.; Pollock, G. Don; Wilson, Harve; Kauffman, Raymond F.; Hayes, J. Scott
- Book ID
- 120728056
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 867 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-2623
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We have synthesized 14C-and 2H-labeled 1,3-dihydro-3,3dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H\_-indol-2one (LY195115), an extremely potent, orally-effective cardiotonic with inotropic and vasodilator activities. '\*C-label was introduced in the antepenultimate step by reaction of a B-
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