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Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase

โœ Scribed by Robertson, David W.; Jones, Noel D.; Krushinski, Joseph H.; Pollock, G. Don; Swartzendruber, John K.; Hayes, J. Scott


Book ID
127376192
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
708 KB
Volume
30
Category
Article
ISSN
0022-2623

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Synthesis of 14C- and 2H-labeled 1,3-dih
โœ David W. Robertson; Joseph H. Krushinski; Don Kau ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 437 KB ๐Ÿ‘ 1 views

We have synthesized 14C-and 2H-labeled 1,3-dihydro-3,3dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H\_-indol-2one (LY195115), an extremely potent, orally-effective cardiotonic with inotropic and vasodilator activities. '\*C-label was introduced in the antepenultimate step by reaction of a B-