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Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

โœ Scribed by Zohra Benfodda; Franck Guillen; Bernard Romestand; Abdelkader Dahmani; Hubert Blancou


Book ID
108116352
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
228 KB
Volume
45
Category
Article
ISSN
0223-5234

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Effect of molecular size on carbonic anh
โœ Kamal Kumar; Mahesh C. Bindal; Prithvi Singh; Satya P. Gupta ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 310 KB

## Abstract The molecular size is found to play an important role in carbonic anhydrase (CA) inhibition by sulfonamides. Significant correlation is obtained between the inhibitory power of __meta__โ€substituted analogs and the van der Waals volume (__V__~__w__~) of the substitutents. This provides a