Highly efficient synthesis of 2′-O-amino
Highly efficient synthesis of 2′-O-amino nucleosides and their incorporation in hammerhead ribozymes
✍
Alexander Karpeisky; Carolyn Gonzalez; Alex B. Burgin; Leonid Beigelman
📂
Article
📅
1998
🏛
Elsevier Science
🌐
French
⚖ 231 KB
2'-O-Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2'-O-amino uridine into position U7 or T-O-amino adenosine into