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Synthesis and incorporation of 2′-amino acid conjugated nucleotides into ribozymes

✍ Scribed by Jasenka Matulic-Adamic; Leonid Beigelman; Lech W. Dudycz; Carolyn Gonzalez; Nassim Usman


Book ID
108038915
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
236 KB
Volume
5
Category
Article
ISSN
0960-894X

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Highly efficient synthesis of 2′-O-amino
✍ Alexander Karpeisky; Carolyn Gonzalez; Alex B. Burgin; Leonid Beigelman 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 231 KB

2'-O-Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2'-O-amino uridine into position U7 or T-O-amino adenosine into