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Highly efficient synthesis of 2′-O-amino nucleosides and their incorporation in hammerhead ribozymes

✍ Scribed by Alexander Karpeisky; Carolyn Gonzalez; Alex B. Burgin; Leonid Beigelman

Book ID: 104258652
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 231 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10784-5

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✦ Synopsis

2'-O-Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2'-O-amino uridine into position U7 or T-O-amino adenosine into position A9 of a hammerhead ribozyme resulted in a slight improvement of catalytic rates.

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