Synthesis and in Vivo Validation of [ O -Methyl- 11 C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2 H -[1,2,4]triazine-3,5-dione: A Novel 5-HT 1A Receptor Agonist Positron Emission Tomography Ligand
✍ Scribed by Kumar, J. S. Dileep; Majo, Vattoly J.; Hsiung, Shu-Chi; Millak, Matthew S.; Liu, Kuo-Peing; Tamir, Hadassah; Prabhakaran, Jaya; Simpson, Norman R.; Van Heertum, Ronald L.; Mann, J. John; Parsey, Ramin V.
- Book ID
- 120049970
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 318 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract 4‐[3‐[4‐(2‐Methoxyphenyl)piperazin‐1‐yl]propoxy]‐4‐aza‐tricyclo[5.2.1.02,6]dec‐8‐ene‐3,5‐dione (4), a potent and selective 5‐HT~1A~ agonist, was labeled by ^11^C‐methylation of the corresponding desmethyl analogue 3 with ^11^C‐methyl triflate. The precursor molecule 3 was synthesized fr
## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor
## Abstract Synthesis of [__O__‐methyl‐^11^C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([^11^C]DMP696), a highly selective CRF~1~ antagonist has been achieved. The total time required for the synthesis of [^11^C]DMP696 is 30 min from EOB usin