A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1-4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis-Arbuzov reaction followed by coupling with uridine-5%-morph
✦ LIBER ✦
Synthesis and in vitro evaluation of substituted aryl- and hetarylmethyl phosphonate and phosphate UMP derivatives as potential glucosyltransferase inhibitors
✍ Scribed by Bhattacharya, Asish K; Stolz, Florian; Kurzeck, Jürgen; Rüger, Wolfgang; Schmidt, Richard R
- Book ID
- 126321042
- Publisher
- NRC Research Press
- Year
- 2002
- Tongue
- French
- Weight
- 139 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0008-4042
- DOI
- 10.1139/v02-119
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