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Design and synthesis of aryl/hetarylmethyl phosphonate-UMP derivatives as potential glucosyltransferase inhibitors

✍ Scribed by Asish K Bhattacharya; Florian Stolz; Richard R Schmidt

Book ID: 104231035
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 68 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00974-1

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✦ Synopsis

A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1-4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis-Arbuzov reaction followed by coupling with uridine-5%-morpholidophosphate as activated UMP derivative.

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