Design and Synthesis of Naphthalenic Derivatives as Potential Inhibitors of Hydroxyindole-O-methyltransferase
✍ Scribed by I. LE PICARD; P. DEPREUX; I. LESIEUR; P. DELAGRANGE; C. BENNEJEAN; P. RENARD; P. VOISIN
- Book ID
- 111710203
- Publisher
- Pharmaceutical Press
- Year
- 1999
- Tongue
- English
- Weight
- 140 KB
- Volume
- 5
- Category
- Article
- ISSN
- 2042-7158
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Applications of Nuclear Magnetic Resonance Spcctroscopy in Organic Chemistry." 2nd cd., Pergamon. Oxford. 1969. p. 204. and references therein. ( I ) I.. Jung and P. Cordicr. Hull. Soc. Phartn. Srrushourg. 8. 89 (1965); through Chrw7. Ahstr.. 66, 31992 (1967). (22) K . Pawclc/yk. K. Adamski,
A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1-4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis-Arbuzov reaction followed by coupling with uridine-5%-morph
Fatty acid biosynthesis is essential for bacterial survival. FabH, b-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Fifty-six 1