14C-labelled 3-(3,4dihydroxy-5-nitrophenylmethylidene)-2,4-pentanedione (4 and 14C-labelled E-N,NdiethyI-Zcyano-3-(3,4-dih droxy 5-nitropheny1)acryl-Key words: carbon-14 labelling, synthesis, COMT-inhibitor. amide (5) have been synthesized from (carbonyl-A Clvanillin.
Synthesis of bridged catechol—homocysteine derivatives as potential inhibitors of catechol O-methyltransferase
✍ Scribed by O. William Lever Jr.; Clifton Hyman; Helen L. White
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 487 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Applications of Nuclear Magnetic
Resonance Spcctroscopy in Organic Chemistry." 2nd cd., Pergamon. Oxford. 1969. p. 204. and references therein.
(
I ) I.. Jung and P. Cordicr. Hull. Soc. Phartn. Srrushourg. 8. 89 (1965); through Chrw7. Ahstr.. 66, 31992 (1967). (22) K . Pawclc/yk. K. Adamski, and E. Stcpien, Farm. Pol.. 28, 285 (1972); through C'hetif. Absrr.. 77. 39352 (1972). (23) A. Albert and E. P. Serjeanl. "The Determination of Ionization Constants," 2nd cd.. Chapman and Ilall. London, 1971. p. 87.
A C K N O W LEIKMENTS
The authors thank William M. Ment and Sharon R . Reed of the Baltimore District I.aboratory. U S . Food and Drug Administration, for calling attention to the possibility of the problem addrcsscd i n this study.
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