Synthesis and in vitro evaluation of some new pyrimidines and related condensed ring systems as potential anticancer agents
โ Scribed by El-Sayed A. M. Badawey
- Book ID
- 112131455
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1996
- Tongue
- English
- Weight
- 338 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Synthesis and evaluation of the antimicrobial and cytotoxic activity of two series of polysubstituted pyrimidines comprising the thioether functionality and other pharmacophores, reported to contribute to various chemotherapeutic activities are described. All newly synthesized compounds
A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the cha