N-Nicotinyl-2-(5-ยฏuorouracil-1-yl)-D,L-glycine (NFG) and N-isonicotinyl-2-(5-ยฏuorouracil-1-yl)-D,L-glycine (INFG) were synthesized as colon-speciยฎc prodrugs of 5-ยฏuorouracil (5-FU). As N-aromatic acyl amides of glycine, they are expected to be stable in the upper intestine and delivered to the colon
โฆ LIBER โฆ
Synthesis and in vitro evaluation of N -nicotinoylglycyl-2-(5-fluorouracil-1-yl)- d , l -glycine as a colon-specific prodrug of 5-fluorouracil
โ Scribed by Lee, Jeoungsoo; Rho, Joohyun; Yang, Youngwook; Kong, Hyesik; Jung, Yunjin; Kim, Youngmi
- Book ID
- 120444590
- Publisher
- Informa plc
- Year
- 2007
- Tongue
- English
- Weight
- 237 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1061-186X
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