## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)
Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT1A receptor
✍ Scribed by Rana Al Hussainy; Joost Verbeek; Dion van der Born; Jan Booij; J(Koos) D.M. Herscheid
- Book ID
- 113583026
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 343 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0223-5234
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