## N-(2-((Substituted Chroman-8-yl)oxy)ethyl)-4-(4-methoxyphenyl) butylamines: Synthesis and Wide Range of Antagonism at the Human 5-HT1A Receptor. -A series of title compounds such as (VIII) and (XIV) as well as unsubstituted and 5-and 7-substituted derivatives are prepared from the correspondin
✦ LIBER ✦
N -[2-[(Substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: Synthesis and Wide Range of Antagonism at the Human 5-HT 1A Receptor
✍ Scribed by Yasunaga, Tomoyuki; Naito, Ryo; Kontani, Toru; Tsukamoto, Shin-ichi; Nomura, Tamako; Yamaguchi, Tokio; Mase, Toshiyasu
- Book ID
- 119964774
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 267 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)