N-Nicotinyl-2-(5-¯uorouracil-1-yl)-D,L-glycine (NFG) and N-isonicotinyl-2-(5-¯uorouracil-1-yl)-D,L-glycine (INFG) were synthesized as colon-speci®c prodrugs of 5-¯uorouracil (5-FU). As N-aromatic acyl amides of glycine, they are expected to be stable in the upper intestine and delivered to the colon
✦ LIBER ✦
Synthesis and properties of N-nicotinoyl-2-(5-fluorouracil-1-yl)-d,l-glycine ester as a prodrug of 5-fluorouracil for rectal administration
✍ Scribed by Young Wook Yang; Jeoung Soo Lee; Inho Kim; Yun Jin Jung; Young Mi Kim
- Book ID
- 116437639
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- French
- Weight
- 191 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0939-6411
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