Synthesis and in Vitro Characterization of an ABC Triblock Copolymer for siRNA Delivery
β Scribed by Segura, Tatiana; Hubbell, Jeffrey A.
- Book ID
- 126009471
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 635 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1043-1802
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π SIMILAR VOLUMES
## Abstract This study describes the synthesis of amphiphilic ABCβtriblock copolymers comprising a central pseudopoly(4βhydroxyβLβproline) segment and terminal hydrophilic poly(ethylene glycol)methyl ether as well as hydrophobic poly(Ξ΅βcaprolactone) blocks. Differential scanning calorimetry, ^1^HβN
A well-defined linear ABC triblock copolymer of ethylene oxide (EO), methyl methacrylate (MMA), and styrene (St) was prepared by sequential living anionic and photo-induced charge transfer polymerization (CTP) using p-aminophenol as parent compound. In the first step, the diblock copolymer of PEO-b-