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Synthesis of amphiphilic pseudopolyamino acid-containing ABC-triblock copolymers and micellar characterizations

✍ Scribed by Ren-Shen Lee; Hua-Rong Li; Fang-Chyou Chiu

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
559 KB
Volume
115
Category
Article
ISSN
0021-8995

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✦ Synopsis

Abstract

This study describes the synthesis of amphiphilic ABC‐triblock copolymers comprising a central pseudopoly(4‐hydroxy‐L‐proline) segment and terminal hydrophilic poly(ethylene glycol)methyl ether as well as hydrophobic poly(ε‐caprolactone) blocks. Differential scanning calorimetry, ^1^H‐NMR spectroscopy, and gel permeation chromatography are used to characterize the copolymers. The thermal properties (T~g~ and __T~m~__s) of the triblock copolymers depend on the composition of polymers. Larger amounts of ε‐CL incorporated into the macromolecular backbone increased T~g~ and __T~m~__s. Fluorescence spectroscopy, transmission electron microscopy, and dynamic light scattering are utilized to investigate their micellar characteristics in the aqueous phase. Observations showed a higher critical micelle concentration with higher hydrophilic components in the copolymers. The micelle exhibited a core‐shell‐corona and/or vesicle shape, and the average size was less than 300 nm. Drug entrapment efficiency and drug loading of micelles depending on the composition of block polymers are also described. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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