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Synthesis and In-Vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties

✍ Scribed by Hyeong Beom Park; Nam Hyun Jo; Joon Hee Hong; Jung Hoon Choi; Jung-Hyuck Cho; Kyung Ho Yoo; Chang-Hyun Oh


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
133 KB
Volume
340
Category
Article
ISSN
0365-6233

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✍ Ki-Hong Nam; Chang-Hyun Oh; Young-Wan Ham; Ki-Soo Lee; Jung-Hyuck Cho 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 359 KB 👁 1 views

The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as st