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Synthesis and Immunobiological Activity of an Original Series of Acyclic Lipid A Mimics Based on a Pseudodipeptide Backbone

✍ Scribed by Martin, Olivier R.; Zhou, Wei; Wu, Xinfu; Front-Deschamps, Sophie; Moutel, Stéphane; Schindl, Katharina; Jeandet, Patricia; Zbaeren, Claude; Bauer, Jacques A.


Book ID
126179746
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
322 KB
Volume
49
Category
Article
ISSN
0022-2623

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We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhib