Synthesis and human applications of stable isotope labelled L-carnitine
✍ Scribed by D.S. Millington; D.A. Maltby; D. Gale; C.R. Roe
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 68 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A method for the production of carboxy‐labelled l‐carnitine is described. The first step is the chemical synthesis of 4‐N‐trimethylammoniobutanoate (butyrobetaine) from the precursors 4‐aminobutanoate and iodomethane. The second step involves the hydroxylation of butyrobetaine to form l
## Abstract Reminyl^®^ is a newly approved drug, used in the treatment of mild to moderate Alzheimer disease. The active compound, galantamine, was initially isolated from the bulbs of certain __Narcissus__ species, but is at the moment also produced synthetically. In the process leading to the fin
## Abstract Commercial (__l__)‐carnitine chloride was N‐demethylated by the action of sodium benzenemercaptide in warm N,N‐dimethylformamide. The product 4‐(N,N‐dimethylammonio)‐3‐hydroxybutanoic acid chloride salt was isolated in good yield by ion exchange chromatography. Methylation of the produc
## Abstract (3,4‐^13^C~2~)‐L‐proline and (^15^N)‐L‐proline were prepared from the correspondingly labeled L‐glumatic acids via a single scheme in high yield and on a gram scale. The synthetic route is based on the ring closure of L‐glutamic acid to L‐5‐oxoproline and the selective reduction of the
The synthesis of a lk-labeled and two stable isotope-labeled analogs of CGS 16617 is described. The synthe tic method involved the preparation of tetrahydro-3--bromo-1-benzazepin-2-one, labeled with a 14C or four deuterium atoms, followed by introduction of two side chains at 1-and 3-positions. Th