Synthesis and evaluation of tripeptidyl α-Ketoamides as human rhinovirus 3C protease inhibitors

✍ Scribed by Shu-Hui Chen; Jason Lamar; Frantz Victor; Nancy Snyder; Robert Johnson; Beverly A. Heinz; Mark Wakulchik; Q.May Wang

• Book ID: 104364070
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 242 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00753-4

✦ Synopsis

We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.