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A High Capacity Microbial Screen for Inhibitors of Human Rhinovirus Protease 3C

โœ Scribed by McCall, J. Owen; Kadam, Sunil; Katz, Leonard


Book ID
109908498
Publisher
Springer Science and Business Media LLC
Year
1994
Tongue
English
Weight
876 KB
Volume
12
Category
Article
ISSN
0733-222X

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Synthesis and evaluation of tripeptidyl
โœ Shu-Hui Chen; Jason Lamar; Frantz Victor; Nancy Snyder; Robert Johnson; Beverly ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 242 KB

We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-1