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Synthesis and evaluation of succinic acid derivatives as prolyl endopeptidase inhibitors

โœ Scribed by Seung-Bin Yoon, Jae-Sung Yang, Kyung-Ho Lee, Hyeon-Gyu Han, Ah-Reum Han, Young-Sook Paik

Book ID
118296511
Publisher
The Korean Society for Applied Biological Chemistry
Year
2011
Tongue
English
Weight
296 KB
Volume
54
Category
Article
ISSN
1738-2203

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Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors.
โœ Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Take ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 174 KB

A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.