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ChemInform Abstract: Synthesis and Evaluation of 2-(Biphenylmethyl)glutaric Acid Amide Derivatives as Neutral Endopeptidase Inhibitors.

โœ Scribed by KANNOH. KANNOH.; K. OSANAI; T. NISHI; M. IINO; S. KATAKURA; T. FURUGOHRI; Y. WATANABE

Book ID
112040580
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and evaluation of 2-(biphenylm
Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors.
โœ Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Take ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 174 KB

A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.