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Synthesis and Evaluation of Peptidyl Michael Acceptors That Inactivate Human Rhinovirus 3C Protease and Inhibit Virus Replication

✍ Scribed by Kong, Jian-she; Venkatraman, Shankar; Furness, Kelly; Nimkar, Sanjay; Shepherd, Timothy A.; Wang, Q. May; Aubé, Jeffrey; Hanzlik, Robert P.


Book ID
119978937
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
205 KB
Volume
41
Category
Article
ISSN
0022-2623

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Synthesis and evaluation of tripeptidyl
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We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-1