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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease

โœ Scribed by Webber, Stephen E.; Tikhe, Jayashree; Worland, Stephen T.; Fuhrman, Shella A.; Hendrickson, Thomas F.; Matthews, David A.; Love, Robert A.; Patick, Amy K.; Meador, James W.; Ferre, Rose Ann


Book ID
111987747
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
350 KB
Volume
39
Category
Article
ISSN
0022-2623

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Synthesis and evaluation of tripeptidyl
โœ Shu-Hui Chen; Jason Lamar; Frantz Victor; Nancy Snyder; Robert Johnson; Beverly ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 242 KB

We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-1