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Synthesis and evaluation of N-acetylneuraminic acid-based affinity matrices for the purification of sialic acid-recognizing proteins

โœ Scribed by Silvana Ciccotosto; Milton J Kiefel; Samia Abo; Wendy Stewart; Kaylene Quelch; Mark von Itzstein


Book ID
110244014
Publisher
Springer US
Year
1998
Tongue
English
Weight
256 KB
Volume
15
Category
Article
ISSN
1573-4986

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## Abstract Bifunctional affinity ligands based on a triazine scaffold were rationally designed to target prion protein and shown to bind recombinant prion protein with high affinity and selectivity. The ligands were capable of discriminating between prion protein glycoforms and monomeric and dimer