The synthesis of 4-methylumbelliferyl α-ketoside of N-acetylneuraminic acid and its use in a fluorometric assay for neuraminidase
✍ Scribed by Robert W. Myers; Reiko T. Lee; Yuan Chuan Lee; George H. Thomas; Linda W. Reynolds; Yoshihiro Uchida
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 664 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0003-2697
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📜 SIMILAR VOLUMES
Glycosidation of N-acetylneuraminic acid by phase-transfer catalysis in chloroform-aqueous alkali gave several known and some new aryl cY-ketosides in a short reaction time and in good yields. The 4-methylumbelliferyl cu-ketoside, the standard substrate for neuraminidase, was prepared in a yield of
It is well known that naturally occurring sialo compounds such as glycoproteins and glycolipids in cell membranes, which play important roles in biological systems'-', contain sialic acids in a-glycosidic linkage. Therefore, a facile, a-selective synthesis of sialic-acid glycosides is very important
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