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Synthesis and Evaluation of N -[ 11 C]Methylated Analogues of Epibatidine as Tracers for Positron Emission Tomographic Studies of Nicotinic Acetylcholine Receptors

✍ Scribed by Horti, Andrew G.; Scheffel, Ursula; Kimes, Alane S.; Musachio, John L.; Ravert, Hayden T.; Mathews, William B.; Zhan, Yougen; Finley, Paige A.; London, Edythe D.; Dannals, Robert F.


Book ID
127071984
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
107 KB
Volume
41
Category
Article
ISSN
0022-2623

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Synthesis of N1β€²-([11C]methyl)naltrindol
✍ John R. Lever; Chris M. Kinter; Hayden T. Ravert; John L. Musachio; William B. M πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 508 KB

## Abstract A delta opioid receptor antagonist, N1′‐methylnaltrindole (MeNTI), has been labeled with carbon‐11. The precursor for radiolabeling was prepared in 71% yield by benzylation of the phenolic moiety of naltrindole. Alkylation of the indole nitrogen using [^11^C]iodomethane and aqueous tetr