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Synthesis and Binding Studies of Epibatidine Analogues as Ligands for the Nicotinic Acetylcholine Receptors.

โœ Scribed by Linjing Mu; Konstantin Drandarov; William H. Bisson; Anita Schibig; Christa Wirz; P. August Schubiger; Gerrit Westera


Publisher
John Wiley and Sons
Year
2006
Weight
10 KB
Volume
37
Category
Article
ISSN
0931-7597

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Tomographic imaging of central nicotinic acetylcholine receptors (nAChRs) via single photon emission computed tomography (SPECT) has been hampered by the lack of a radioligand with suitable in vivo binding characteristics. Therefore, a novel analog of epibatidine, (6)-exo-2-(2-iodo-5-pyridyl)-7-azab