## Abstract As a continuation of our studies on bicyclic heterocycles with benzodiazepine receptor affinity, derivatives with a 5:5 bicyclic skeleton, namely imidazo[2,1β__b__]thiazoles, imidazo[2,1β__b__]imidazoles and pyrrolo[1,2β__c__]imidazoles were prepared. The compounds possessed an aromatic
Synthesis and Evaluation of Imidazo[2,1-b]thiazoles as Iodide Efflux Inhibitors in Thyrocytes
β Scribed by Nathalie Lecat-Guillet; Yves Ambroise
- Book ID
- 102105020
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 423 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1860-7179
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A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
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