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Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists

✍ Scribed by Jun Wei; Michele F. Rega; Shinichi Kitada; Hongbin Yuan; Dayong Zhai; Prabhakar Risbood; Herbert H. Seltzman; Charles E. Twine; John C. Reed; Maurizio Pellecchia

Book ID
116334936
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
387 KB
Volume
273
Category
Article
ISSN
0304-3835

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The lower molecular weight analog 12 of sialyl Lewis x was prepared and effected equal binding affinity to E-and P-selectin compared to the parent tetrasaccharide. If 12 was prepared using acidic ion exchange resins, false positive test were produced, especially binding to P-selectin seemed to be co