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Synthesis and Evaluation of a Conformationally Constrained Pyridazinone PNA-Monomer for Recognition of Thymine in Triple-Helix Structures.

โœ Scribed by Anne Goldbech Olsen; Otto Dahl; Peter E. Nielsen


Book ID
101967465
Publisher
John Wiley and Sons
Year
2004
Weight
143 KB
Volume
35
Category
Article
ISSN
0931-7597

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โœ Akiko Saito; Reiko Kuroda ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 208 KB

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of trip