✦ LIBER ✦

Design and synthesis of a new type of modified nucleoside for triple helix-mediated adenine-thymine base pair recognition: Formation of hydrogen bonds to the far-side adenine

✍ Scribed by Akiko Saito; Reiko Kuroda

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 208 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00857-6

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✦ Synopsis

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of triplex-forming modified nucleoside which are expected to act as DNA cleaving agents through the p-nitrophenyl group.