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Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates

โœ Scribed by Mamta Dadwal; Chi Soo Kang; Hyun A. Song; Xiang Sun; Anzhi Dai; Kwamena E. Baidoo; Martin W. Brechbiel; Hyun-Soon Chong

Book ID
113495920
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
199 KB
Volume
21
Category
Article
ISSN
0960-894X

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Evaluation of desferal as a bifunctional
Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89
โœ Wilma E. Meijs; Jacobus D.M. Herscheid; Hidde J. Haisma; Herbert M. Pinedo ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science โš– 472 KB

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro st