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Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

โœ Scribed by Wilma E. Meijs; Jacobus D.M. Herscheid; Hidde J. Haisma; Herbert M. Pinedo

Book ID
103922895
Publisher
Elsevier Science
Year
1992
Weight
472 KB
Volume
43
Category
Article
ISSN
0883-2889

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โœฆ Synopsis

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

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