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Synthesis and Evaluation of 11C-Labeled Nonpeptide Antagonists for Cholecystokinin Receptors: [11C]L-365,260 and [11C]L-365,346

✍ Scribed by Terushi Haradahira; Osamu Inoue; Kaoru Kobayashi; Kazutoshi Suzuki

Book ID
117688214
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
231 KB
Volume
25
Category
Article
ISSN
0969-8051

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## Abstract We demonstrated the synthesis of carbon‐11 labeled 17‐__Ξ±__‐hydroxy‐11‐__Ξ²__‐/4‐/[methyl]‐[1‐methylethyl]‐aminophenyl/‐17__Ξ±__‐[prop‐1‐ynyl]esta‐4‐9‐diene‐3‐one (RU40555), a selective glucocorticoid receptor (GR) antagonist, and examined the __in vivo__ profile of [^11^C]RU40555. [^11^