Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization. The linked compounds protect DNA from restriction en&m&eases and reversibly crosslink DNA.
✦ LIBER ✦
Synthesis and DNA crosslinking by a rigid CPI dimer
✍ Scribed by Mitchell, Mark A.; Kelly, Robert C.; Wicnienski, Nancy A.; Hatzenbuhler, Nicole T.; Williams, Marta G.; Petzold, Gary L.; Slightom, Jerry L.; Siemieniak, David R.
- Book ID
- 125994968
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 811 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0002-7863
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