✍ Scribed by Dr. Didier M. Lambert; Bernard Gallez; Jacques H. Poupaert
No coin nor oath required. For personal study only.
-glycine, a lipophilic derivative of glycine exhibiting anticonvulsant properties, was prepared in one step from [U-14C) glycine and benzyl chloroformate in alkali medium. A comparative study of biodistribution was carried on mice between this compound and the parent amino-acid after intravenous administration. Dimethylsulfoxide was used as injection vehicle for N-benzyloxycarbonylglycine. The influence of this injection vehicle was studied comparing glycine injected in a saline solution and glycine co-administered with dimethylsulfoxide. No significant difference was found between these two treatments.
Compared to glycine, N-benzyloxycarbonylglycine reached quickly the central nervous system and exhibited an enhanced brain penetration index, 13-fold superior to the parent aminoacid value.
📜 SIMILAR VOLUMES
## Abstract N‐(Feruloyl‐2‐^14^C)‐glycine‐2‐^3^H (IX) was obtained with an acceptable yield (43%) starting from O‐methoxycarbonyl‐ferulic acid‐2‐^14^C (IV) and glycine‐2‐^3^H ethyl ester (VI). The latter two compounds were first condensed into N‐(O‐methoxycarbonyl‐feruloyl‐2‐^14^C)‐glycine ‐2‐^3^H e
## Abstract [Cys‐^14^CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐^14^CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [^14^C] cyanide. This labelled compound was used to obtain [Cys‐^14^CO] with a yield of 15%. [
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