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N- acylamino acids and peptides III. The synthesis of N- (feruloyl-2-14C)-glycine-2-3H

✍ Scribed by H. De Pooter; I. Pé; C. F. Van Sumere

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
264 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

N‐(Feruloyl‐2‐^14^C)‐glycine‐2‐^3^H (IX) was obtained with an acceptable yield (43%) starting from O‐methoxycarbonyl‐ferulic acid‐2‐^14^C (IV) and glycine‐2‐^3^H ethyl ester (VI). The latter two compounds were first condensed into N‐(O‐methoxycarbonyl‐feruloyl‐2‐^14^C)‐glycine ‐2‐^3^H ethyl ester (VII) using anisoyl chloride (X) and the mixed anhydride method (?). Subsequently VII was transformed into N‐(feruloyl‐2‐^14^C)‐glycine‐2‐^3^H (IX) by alkaline hydrolysis. The specific activities of the compound were respectively 12.64 μCi (^3^H)/μmole and 1.71 μCi (^14^C)/μmole.

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