A route to 1,2\_dihydropyridines &-substituted with chiral auxiliaries has been developed starting from commercially available chiral amines. Cycloaddition between these dihydropyridines and methyl acrylate gave, in moderate d.e., isoquinuclidines of good enantiomeric purity whose absolute configura
Synthesis and Determination of the Absolute Configuration of Chiral Tetracosanaphthalenes
โ Scribed by Tsubaki, Kazunori; Takaishi, Kazuto; Sue, Daisuke; Kawabata, Takeo
- Book ID
- 127095779
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 190 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
## Abstract A versatile system for preparing macrocyclic compounds with planar chirality is presented. In this system chiral diazacoronands are synthesized readily from lariatโtype diesters **13** and **14** and unsymmetrical diamines **7, 8, 12, 15**, and **16** under nonโhighโdilution conditions.
Sutmnary: Absolute configurations of axially chiral biaryls with hydroxyl, amino, and carboxyl groups can be easily determined by pmr spectra using MTPA derivatives and shift reagents. Recently chiral biaryls have been successfully utilized in the field of asynetric synthesis\*. For example, virtual
By the use of a new axially chiral reagent, 2'-methoxy-l,l'-binaphthalene-2-carbohydroximoyl chloride (MBCC), chiral cyclic alkenes were stereoselectively derivatized into 4,5-dihydroisoxazoles. NOEs were observed between the protons of the reagent moiety and those of the alkene moiety in cycloadduc