Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin
✍ Scribed by Liu, Jian-Fei; Sang, Chun-Yan; Xu, Xiao-Hui; Zhang, Lin-Lin; Yang, Xuan; Hui, Lin; Zhang, Jin-Bang; Chen, Shi-Wu
- Book ID
- 120353226
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 659 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0223-5234
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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐
## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p