✍ Scribed by M. A. A. Awas
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5-Acetyl-4,5-dihydro-1-phenylpyrazolo[3,4-d]pyrimidin-4-one was prepared and subjected to various chemical transformations to give novel 5-heterocyclic pyrazolopyrimidinone derivatives of expected important biological activity. Then, the latter compounds were used to obtain β-keto ester and α,β-unsaturated carbonylpyrazolopyrimidinones which were used as alternate precursors to produce new pyrazolopyrimidinones substituted with five-membered heterocycles such as pyrazole and isoxazole. The structure of these compounds was identified on the basis of their chemical behaviour as well as elemental and spectral analysis.
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received in UK for plblicrtian 4 Maroh 1974) Addition of tert-butyl trimethylsilylacetatel to tetrahydrofuran (THF) solutions of lithium diisopropylamide at -78' produces the lithimn ester enolate, I, (eq 1) as a white precipitate. Attempts to isolate I have been unsuccessful; however, suspensions o