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Reaction of lithio tert-butyl trimethylsilylacetate with aldehydes and ketones. A synthesis of α,β-unsaturated esters.

✍ Scribed by Stephen L. Hartzell; Donald F. Sullivan; Michael W. Rathke

Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
164 KB
Volume
15
Category
Article
ISSN
0040-4039

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✦ Synopsis

received in UK for plblicrtian 4 Maroh 1974) Addition of tert-butyl trimethylsilylacetatel to tetrahydrofuran (THF) solutions of lithium diisopropylamide at -78' produces the lithimn ester enolate, I, (eq 1) as a white precipitate. Attempts to isolate I have been unsuccessful; however, suspensions of I in THF are stable

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