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Synthesis and crystal structure of 2-phosphonoalkyl-1, 2-benzisoselenazol-3(2H)-ones and their antitumor activities

✍ Scribed by Jia Zhou; Ruyu Chen

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 200 KB
Volume: 10
Category: Article
ISSN: 1042-7163
DOI: 10.1002/(sici)1098-1071(1999)10:3<247::aid-hc12>3.0.co;2-c

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✦ Synopsis

The title compounds were synthesized in good yields by the condensation reaction of diphenyl ␣-aminoalkylphosphonates with 2-(chloroseleno)benzoyl chloride. Their structures were confirmed by spectroscopic methods and microanalyses. The X-ray analyses showed that the selenium-containing fused ring has a planar structure and that, by the molecular packing of the unit cells, two adjacent molecules are symmetrically linked to each other through Se(1c) . . . O‫ס‬P(1) bonding interactions with an intermolecular Se(1c) . . . O distance of 2.797 A ˚. The results of bioassay indicated that some of these compounds possess potent antitumor activities against some human carcinoma cells in vitro.

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