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Synthesis and conformational preferences of unnatural tetrapeptides containing l-valine units

✍ Scribed by Daniele Balducci; Andrea Bottoni; Matteo Calvaresi; Gianni Porzi; Sergio Sandri


Book ID
108284166
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
554 KB
Volume
17
Category
Article
ISSN
0957-4166

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πŸ“œ SIMILAR VOLUMES


Stereocontrolled Synthesis of Unnatural
✍ Daniele Balducci; Gianni Porzi πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 German βš– 306 KB

## Abstract The stereoselective synthesis of the new nonproteinogenic branched tetrapeptides **9a**–**9d** and **15a**,**b**, containing two L‐valine units and unnatural __Ξ±__‐amino acids, was accomplished starting from the chiral synthon **1a**, a monolactim ether easily obtained from L‐valine.

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## Abstract The crystal structure and conformation of the synthetic cyclic tetrapeptide, __cyclo__(L‐Pro‐Sar)~2~, was determined by x‐ray analysis. The peptide crystallizes in the orthorhombic space group __P__2~1~2~1~2~1~ with cell parameters __a__ = 9.277(1), __b__ = 12.884(1), and __c__ = 15.581

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## Abstract The conformational preferences in solution of eight new open‐chain and cyclic aromatic sulphides containing pyridine or 1,3,4‐thiadiazole units have been investigated, parallel to those of some structurally related phenyl sulphides, by means of ^1^H NMR spectroscopy. The results obtaine