## Abstract Starting with the Οβhydroxy and Οβamino acid derivatives **13** and **21**, the two closely related geodiamolide analogs **32** and **35**, respectively, were prepared. Compared to the natural cyclodepsipeptide geodiamolide (**1**), the macrocycles **32** and **35** have a smaller ring
β¦ LIBER β¦
Synthesis and conformational analysis of two 2-oxopiperazine-containing tetrapeptide analogues
β Scribed by POHLMANN, ADRIANA ;GUILLAUME, DOMINIQUE ;QUIRION, JEAN-CHARLES ;HUSSON, HENRI-PHILIPPE
- Book ID
- 110893655
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 439 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1397-002X
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The new C a -tetrasubstituted a-amino acid residue 2- [2-(methylthio)ethyl]methionine (Dmt) has been introduced into the reference chemotactic tripeptide HCO-Met-Leu-Phe-OMe ( f MLP-OMe) in place of the leucine or methionine, respectively. The biological activity of the new analogues [Dmt 2 ] f MLP-