Synthesis and conformational analysis of cyclic pentapeptide endothelin antagonists
โ Scribed by LIN, MENGFEN ;CHAN, MING FAI ;BALAJI, V.N. ;CASTILLO, ROSARIO S. ;LARIVE, CYNTHIA K.
- Book ID
- 115099880
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 910 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0367-8377
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๐ SIMILAR VOLUMES
A comparative conformational analysis of two short pseudopeptides with ETB receptor affinity has been performed by molecular modelling and NMR techniques. This analysis aimed to get insight into probable biorelevant conformations and pharmacophoric patterns necessary for an efficient interaction wit
~~~~of~~~~c~~~~~ isolated from&&r ilcrlorieus, was umductcd by 2D-NMI2 techniques, tempcratun effects on NH protons, rate of hydrogen-dcuterium exchange, vicinal NH--H coupling coustants, and NOE experiments. The methods of molecular me&a&s and restrained molecular dynamics calculati~s were applied