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Solution conformation of a cyclic pentapeptide endothelin antagonist Comparison of structures obtained from constrained dynamics and conformational search

โœ Scribed by Stanley R. Krystek Jr.; Donna A. Bassolino; Robert E. Bruccoleri; John T. Hunt; Michael A. Porubcan; Charles F. Wandler; Niels H. Andersen


Book ID
115925826
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
651 KB
Volume
299
Category
Article
ISSN
0014-5793

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โœ Guillermo Moyna; Howard J. Williams; Ronald J. Nachman; A. I. Scott ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 206 KB ๐Ÿ‘ 2 views

The preferred conformations of the active diuretic insect kinin pentapeptide analogue Phe-Phe-Aib-Trp-Gly-NH 2 were studied using nmr spectroscopy and molecular modeling. Structure sets consistent with rotating frame nuclear Overhauser effect spectroscopy distance constraints obtained by restrained